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As an important method of systems biology, metabolomics not only plays an important role in life science but also has been increasingly widely used in radiation protection research. Based on the clinical studies of metabolomics and metabolomics methods in rodent and primate models, this article summarizes the methods and techniques of metabolomics in the diagnosis of radiation damage, the study of radiation damage mechanisms, and the development of radiation protection drugs.
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Objective To investigate the effect of three -dimensional ultrasound in the diagnosis of uterine abnormalities.Methods From January2017 toDecember 2017,50 patients with uterineabnormalities admitted to the Maternal and Child Health Care Hospital of Cixi were selected .GE Voluson E8 high -resolution color Doppler ultrasound system were used for all patients to conduct two -dimensional ultrasound and three-dimensional ultrasound examinations.The results of the two methods ,including the time taken for the inspection and the correctness of the inspection were compared.Results The time used for three -dimensional ultrasonic testing[(2.39 ±0.25)min] and the accuracy of inspection (100％) were better than two -dimensional ultrasonic testing[(5.77 ±0.66)min, 80％],the differences were statistically significant (t=33.864,χ2 =11.111,all P <0.05).Conclusion Three -dimensional ultrasonography can accurately present the external contour of the uterus and the shape of the intima .The abnormal uterus can be timely discovered.At the same time,it has advantages of non -invasive and safe.
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Glucose transporter type 1 deficiency syndrome is a rare neurometabolic disorder caused by mutations of the solute carrier family 2 facilitated glucose transporter member 1 (SLC2A1) gene,characterized by complex manifestations including early onset epilepsy,motor and mental retardation,and movement disorders and so on.Ketogenic-diet is most suitable therapy and should be commenced as early as possible because timing the initiation of the diet may prevent seizure,movement disorder,and cognitive impairment.This review aims to improve the clinicians' understanding of glucose transporter type 1 deficiency syndrome to ensure the diagnosis as early as possible.
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Glucose transporter type 1 deficiency syndrome is a rare neurometabolic disorder caused by mutations of the solute carrier family 2 facilitated glucose transporter member 1 (SLC2A1) gene, characterized by complex manifestations including early onset epilepsy, motor and mental retardation, and movement disorders and so on. Ketogenic-diet is most suitable therapy and should be commenced as early as possible because timing the initiation of the diet may prevent seizure, movement disorder, and cognitive impairment. This review aims to improve the clinicians′ understanding of glucose transporter type 1 deficiency syndrome to ensure the diagnosis as early as possible.
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Objective@#To investigate the effect of three-dimensional ultrasound in the diagnosis of uterine abnormalities.@*Methods@#From January 2017 to December 2017, 50 patients with uterine abnormalities admitted to the Maternal and Child Health Care Hospital of Cixi were selected.GE Voluson E8 high-resolution color Doppler ultrasound system were used for all patients to conduct two-dimensional ultrasound and three-dimensional ultrasound examinations.The results of the two methods, including the time taken for the inspection and the correctness of the inspection were compared.@*Results@#The time used for three-dimensional ultrasonic testing[(2.39±0.25)min] and the accuracy of inspection (100%) were better than two-dimensional ultrasonic testing[(5.77±0.66)min, 80%], the differences were statistically significant (t=33.864, χ2=11.111, all P<0.05).@*Conclusion@#Three-dimensional ultrasonography can accurately present the external contour of the uterus and the shape of the intima.The abnormal uterus can be timely discovered.At the same time, it has advantages of non-invasive and safe.
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Objective To investigate the early clinical efficacy of Masquelet membrane induction technique in the treatment of traumatic long bone defects.Methods A retrospective case series study was conducted to analyze the clinical data of 41 patients with traumatic long bone defects admitted to the General Hospital of the Northern Theater Command from January 2012 to April 2017.There were 36 males and five females,aged 15-70 years,with an average of 38.2 years.There were 20 patients with bone defect at the femur,19 at the tibia,one at the fibula,and one at the ulna.All patients received staged treatment using the Masquelet membrane induction technique.In stage Ⅰ surgery,thorough debridement was first performed,and the secretions were taken for bacterial culture.The average bone defect length after debridement was 6.9 cm (2.0-18.5 cm).The bone defect was filled with antibiotic bone cement to induce the biofilm formation.If the postoperative bacterial culture showed positive results,debridement surgery was performed again.Stage Ⅱ surgery was performed after 6-12 weeks.The white blood cell count,C-reactive protein (CRP),procalcitonin (PCT),erythrocyte sedimentation rate (ESR) were measured before the operation.During the operation,bone biopsy was performed,and the bone cement placeholder was completely removed.The autologous cancellous bone and artificial bone were implanted in the bone defect areas,and the induced membrane was sutured.The healing time of bone defects was recorded,and the Paley fracture healing scoring criteria were used to evaluate the limb function.The complications were observed.The inflammatory markers were reviewed at the last follow-up.Results All patients were followed up for 7-36 months with an average of 13.6 months.A total of 37 patients obtained bone healing.The fracture healing rate of stage Ⅰ was 90％,and the healing time was 6-13 months,with an average of 9 months.According to the Paley fracture healing scoring criteria,the results were excellent in 25 patients,good in 10,and fair in two patients,with the excellent and good rate of 85％.In terms of complications,one patient with superficial infection recovered after dressing change,three patients had deep infection,of which one patient was treated with amputation and two received other treatments,and three patients were treated with membrane induction again because of bone resorption.At the last follow-up,there were significant differences between preoperative and postoperative White blood cell count,CRP,PCT and ESR(P ＜ 0.05).Conclusion For traumatic long bone defects,Masquelet membrane induction technique can promote fracture healing,restore limb function and reduce complications.
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Objective To investigate the bacterial spectrum and drug resistance of bone infection after multiple hospitalizations.Methods A retrospective case series study was conducted on 95 patients with bone infection due to injuries admitted in the General Hospital of Shenyang Military Area from January 2009 to December 2016.There were 76 males and 34 females,with an average age of 47 years (range,17-94 years).Bacterial culture and drug sensitivity tests were performed in 246 specimens of the infection secretions and infected tissues.The bacterial species and drug resistance data of all the specimens were statistically analyzed.The numbers and ratios of Gram-positive bacteria and Gram negative bacteria were counted according to the changes of hospitalization frequency,and the changes of drug resistance of Staphylococcus aureus after repeated hospitalizations were also recorded.Results A total of 110 pathogenic bacteria were isolated,and mixed infection was found in 19％ of the bacteria.There were 61 Gram-positive bacteria (55.5％),including 35 Staphylococcus aureus [seven methicillin-resistant staphylococcus (MRSA) strains],accounting for 57％ of Gram-positive strains.Other Gram positive bacteria were mainly Enterococcus faecalis and Staphylococcus epidermidis.There were 48 Gram-negative bacteria (43.6％),including 12 Pseudomonas aeruginosa strains,accounting for 25％ of Gram-negative strains,nine Klebsiella pneumoniae strains,accounting for 19％ of the Gramnegative strains.Staphylococcus aureus had a resistance rate to penicillin of 82％,and the major Gram positive bacteria (Staphylococcus aureus,Enterococcus faecalis,Staphylococcus epidermidis) were all highly sensitive to vancomycin and linezolid.The major Gram-negative bacteria (Pseudomonas aeruginosa,Klebsiella pneumoniae,Escherichia coli,Acinetobacter baumannii) were highly resistant to the second generation of cephalosporins and were sensitive to carbapenem antibiotics.In 95 bone infection patients,the ratio of Gram positive bacteria to Gram negative bacteria increased from 0.98 at the first admission to 3 after repeated hospitalizations,and the ratio change was statistically significant (P ＜0.05).After multiple hospitalizations,the drug resistance of Staphylococcus aureus to gentamicin,ciprofloxacin,levofloxacin,and tetracycline increased gradually.The resistance rate to penicillin was even up to 100％.Conclusions The mixed infection of bone infection is common,among which Staphylococcus aureus and Staphylococcus epidermidis are the main Gram-positive pathogenic bacteria,Pseudomonas aeruginosa and Klebsiella pneumoniae are the main Gram negative pathogenic bacteria.The proportion of Gram-positive bacteria infection increased after multiple hospitalizations and became the major pathogenic bacteria.Penicillin should be avoided in the treatment of Staphylococcus aureus infection in multiple hospitalizations,and gentamicin and ciprofloxacin should be used with caution.Vancomycin or linezolid which is more sensitive is a better option.
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Objective To investigate the cancer-related fatigues in oral cancer patients.Methods One hundred oral cancer patients were involved in the survey with self-designed general information questionnaire,revised Piper fatigue correction scale(RPFS).Results Seventy six cases(76.00%)had different degree of fatigue.The total score of RPFS was(5.51+1.23)points. In the descending order of scores,the dimensions were body fatigue,emotional fatigue,behavioral fatigue and cognitive fatigue. Conclusions Oral cancer patients have cancer-related fatigue commonly,with body fatigue the most intense and emotional fatigue at a higher level.Therefore,medical staff should ensure patients intake of enough nutrients in order to reduce the body fatigue and meanwhile should instruct patients to handle their bad moods correctly so as to relieve their metal fatigue.